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Ligandrol , also known as LGD-4033 is a popular testosterone boosting supplement that works as a selective androgen receptor modulator (SARM)to increase the levels of androgen receptors [ 1 , 2 ]. In order to provide the greatest benefit to the endometrial lining, testosterone should be administered via oral administration to the endometrium. It is often used to enhance the endometrial weight loss and decrease the risk of implantation complications during hormone therapy [ 1 ]. To minimize the risk of false positive results, patients were excluded if their primary outcome measure was a change from the pretreatment mean baseline value, the change from the placebo group mean baseline value, or the change from the comparison group mean baseline value. This was done because at least 2 measures were provided and the most common reasons for false positive results were the use of a reference or a different method of measurement from that being compared to. Incomplete results in this analysis (n = 5) excluded the need to re-evaluate the efficacy of the study in this group. However, as our intention to report the effectiveness of the study was based on our ability to detect statistically significant differences between the groups, we omitted the analysis for the complete cases where the outcome was not statistically significant. Thus the total study cohort consisted of 28 women. To avoid potential bias in the calculation of the efficacy of the study using the primary outcome measure, women who had undergone a prior hysterectomy were excluded from the study. We further excluded women who had had a previous procedure, cancer, vascular disease, and use of oral contraceptives (the 2 types of estrogen containing products the study utilized) before beginning treatment, since we hypothesize the women may use different types of hormone replacement in their menstrual cycle, or have used estrogen and progestins as part of a cycle treatment regimen for the menstrual cycle, which could affect our results. We analyzed our study cohorts using the Satterthwaite equation, which describes the relationship between changes in endometrial weight and change in androgen receptor (AR) mRNA expression. This equation can be found in the Appendix [ 29 ]. AR expression is defined as AR activity + mRNA. The change is expressed as a ratio between the change over time from pre- to post-treatment relative to the change relative to the reference group at the beginning of the study, and for the comparison group relative to the reference group at the end of the study, using the following formula: Women were enrolled in the study between January 2004 and December 2006. The study was started because estrogen replacement therapy in combination with progestin has been associated with increased risk for breast cancer and ovarian cancer [ 15 Related Article: